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Daunorubicin interacts with DNA by intercalation and inhibition of macromolecular biosynthesis. This inhibits the development in the enzyme topoisomerase II, which relaxes supercoils in DNA for transcription.
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Epirubicin is favoured around doxorubicin, the most well-liked anthracycline, in some chemotherapy regimens since it appears to bring about fewer Negative effects. In 1999 epirubicin received FDA get more info approval as a part of adjuvant therapy in node-good clients.